Colistimethate sodium

 

Colistimethate sodium is a prodrug of colistin (polymyxin E) which is a mixture of polypeptide antibiotics active against Gram-negative bacteria, including Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.

 

Indication: Used in the treatment of acute or chronic infections due to sensitive strains of Gram-negative pathogens, especially in patients with limited treatment options.

 

Application: Administered systemically as intramuscular injections and intravenous injections or infusions. Colistimethate sodium can also be administered by inhalation or mixed with bone cement, as well as used in ophthalmic formulations.